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Article

Genetics of high level penicillin resistance in clinical isolates ofStreptococcus pneumoniae

1 Mar 1995

Abstract excerpt

Mosaic penicillin-binding proteins (PBP) 1A, 2X and 2B genes were cloned from four clinical isolates of Streptococcus pneumoniae with levels of susceptibility to penicillin ranging from 1.5 to 16 micrograms benzylpenicillin ml-1. In each instance it was possible to transform either the penicillin-sensitive laboratory strain R6 or a sensitive clinical isolate 110K/70 to the full level of penicillin resistance with...

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PMID: 7729674
DOI: 10.1111/j.1574-6968.1995.tb07433.x

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