Article
Single and multiple congenic strains for hydrocephalus in the H-Tx rat.
Mammalian genome : official journal of the International Mammalian Genome Society - 1 Apr 2005
Jones Hazel C, Chen Gin-Fu, Yehia Baligh R, Carter Barbara J, Akins Elizabeth J, Wolpin Logan C
Abstract excerpt
The H-Tx rat has fetal-onset hydrocephalus with a complex mode of inheritance. Previously, quantitative trait locus mapping using a backcross with Fischer F344 rats demonstrated genetic loci significantly linked to hydrocephalus on Chromosomes 10, 11, and 17. Hydrocephalus was preferentially associated with heterozygous alleles on Chrs 10 and 11 and with homozygous alleles on Chr 17. This study aimed to determine...
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