Article
Generation of congenic and consomic rat strains.
Methods in molecular biology (Clifton, N.J.) - 1 Jan 2010
Lagrange Dominique, Fournié Gilbert J
Abstract excerpt
Congenic and consomic rat strains are inbred strains containing in their genome a given genomic region (congenic) or a whole chromosome (consomic) from another strain. They are nowadays invaluable tools for the identification of genes and mechanisms of multifactorial diseases, one of the main goals in biomedicine. They are produced by repeated backcrosses from a donor inbred strain to a recipient inbred strain,...
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