Article
Chromosomal linkage associated with disease severity in the hydrocephalic H-Tx rat.
Behavior genetics - 1 Jan 2001
Jones H C, Carter B J, Depelteau J S, Roman M, Morel L
Abstract excerpt
Infantile hydrocephalus results in neurological deficits despite surgical treatment. Fetal-onset hydrocephalus in humans can be caused by developmental abnormalities that are genetic in origin. The H-Tx rat has hydrocephalus with 40% penetrance and a polygenic inheritance. A backcross with Fisher F344 inbred strain produced a total of 1500 progeny with 17.5% hydrocephalus. Of these, only 12.3% had overt disease...
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