Article
Loss of linkage disequilibrium and accelerated protein divergence in duplicated cytomegalovirus chemokine genes.
Virus genes - 1 Aug 2005
Arav-Boger Ravit, Zong Jian-Chao, Foster Charles B
Abstract excerpt
Human CMV (hCMV) encodes several captured chemokine ligand and chemokine receptor genes that may play a role in immune evasion. The adjacent viral alpha-chemokine genes UL146 and UL147 appear to have duplicated subsequent to a recent gene capture event. Sequence data from multiple hCMV isolates suggest accelerated protein evolution in one of the paralogues, UL146. Extensive sequence variation was noted throughout...
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