Article
Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice.
Nature - 10 Aug 2000
Artandi S E, Chang S, Lee S L, Alson S, Gottlieb G J, Chin L, DePinho R A
Abstract excerpt
Aged humans sustain a high rate of epithelial cancers such as carcinomas of the breast and colon, whereas mice carrying common tumour suppressor gene mutations typically develop soft tissue sarcomas and lymphomas. Among the many factors that may contribute to this species variance are differences in telomere length and regulation. Telomeres comprise the nucleoprotein complexes that cap the ends of eukaryotic...
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