Article
Identification of antimicrobial compounds active against intracellular Staphylococcus aureus.
FEMS immunology and medical microbiology - 1 Aug 2005
Malouin François, Brouillette Eric, Martinez Alejandro, Boyll Bobbi J, Toth James L, Gage Jennifer L, Allen Norris E
Abstract excerpt
Small-colony variants (SCVs) of Staphylococcus aureus exhibit characteristics of bacteria that can penetrate mammalian cells and remain intracellular and innocuous for indefinite periods. These properties make SCVs a convenient tool that can be used to identify new antibacterial agents having activity against intracellular, quiescent bacteria. Agents active against SCVs could be useful in the treatment of chronic...
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