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Article

Nonstable Staphylococcus aureus Small-Colony Variants Are Induced by Low pH and Sensitized to Antimicrobial Therapy by Phagolysosomal Alkalinization.

The Journal of infectious diseases - 15 Jan 2016

Leimer Nadja, Rachmühl Carole, Palheiros Marques Miguel, Bahlmann Anna Sophie, Furrer Alexandra, Eichenseher Fritz, Seidl Kati, Matt Ulrich, Loessner Martin J, Schuepbach Reto A, Zinkernagel Annelies S

Abstract excerpt

BACKGROUND: Staphylococcus aureus-infected patients treated with antibiotics that are effective in vitro often experience relapse of infection because the bacteria hide in privileged locations. These locations include abscesses and host cells, which contain low-pH compartments and are sites from which nonstable S. aureus small-colony variants (SCVs) are frequently recovered. METHODS: We assessed the effect of low...

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PMID: 26188074
DOI: 10.1093/infdis/jiv388

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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