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Natural history of seminiferous tubule degeneration in Klinefelter syndrome

19 Sept 2005

Abstract excerpt

Klinefelter syndrome (47,XXY) is characterized by small, firm testis, gynaecomastia, azoospermia and hypergonadotropic hypogonadism. Degeneration of the seminiferous tubules in 47,XXY males is a well-described phenomenon. It begins in the fetus, progresses through infancy and accelerates dramatically at the time of puberty with complete hyalinization of the seminiferous tubules, although a few tubules with...

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PMID: 16172111
DOI: 10.1093/humupd/dmi039

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