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Article

Histologic features of sinus histiocytosis with massive lymphadenopathy in patients with autoimmune lymphoproliferative syndrome.

The American journal of surgical pathology - 1 Jul 2005

Maric Irina, Pittaluga Stefania, Dale Janet K, Niemela Julie E, Delsol Georges, Diment Judith, Rosai Juan, Raffeld Mark, Puck Jennifer M, Straus Stephen E, Jaffe Elaine S

Abstract excerpt

Autoimmune lymphoproliferative syndrome (ALPS) is an inherited disorder associated with defects in Fas-mediated apoptosis, characterized most often by childhood onset of lymphadenopathy, splenomegaly, hypergammaglobulinemia, and autoimmune phenomena. Children with sinus histiocytosis with massive lymphadenopathy (SHML) have a somewhat similar clinical phenotype in which prominent adenopathy also is associated...

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Identifiers

PMID: 15958855
DOI: 10.1097/01.pas.0000157997.61177.08

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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