Article
Biological consequences of petite mutations in Candida glabrata.
The Journal of antimicrobial chemotherapy - 1 Aug 2005
Brun Sophie, Dalle Frédéric, Saulnier Patrick, Renier Gilles, Bonnin Alain, Chabasse Dominique, Bouchara Jean-Philippe
Abstract excerpt
OBJECTIVES: To define the pathogenicity of respiration-deficient mutants of Candida glabrata, which present a reduced susceptibility to azoles, that are easily induced in vitro by exposure to these drugs or to ethidium bromide and that may be selected in vivo in patients receiving fluconazole. METHODS: Two wild-type isolates of C. glabrata were compared with their respective fluconazole- or ethidium...
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