Article
Relationships between respiration and susceptibility to azole antifungals in Candida glabrata.
Antimicrobial agents and chemotherapy - 1 Mar 2003
Brun Sophie, Aubry Christophe, Lima Osana, Filmon Robert, Bergès Thierry, Chabasse Dominique, Bouchara Jean-Philippe
Abstract excerpt
Over the past two decades, the incidence of infections due to Candida glabrata, a yeast with intrinsic low susceptibility to azole antifungals, has increased markedly. Respiratory deficiency due to mutations in mitochondrial DNA (mtDNA) associated with resistance to azoles frequently occurs in vitro in this species. In order to specify the relationships between respiration and azole susceptibility, the effects of...
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