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Article

High prevalence of two BRCA1 mutations, 4154delA and 5382insC, in Latvia.

Familial cancer - 1 Jan 2005

Tikhomirova Laima, Sinicka Olga, Smite Dagnija, Eglitis Janis, Hodgson Shirley V, Stengrevics Aivars

Abstract excerpt

Our aim was to characterise the germline BRCA1 mutation profile in Latvian breast cancer and ovarian cancer patients, to develop an effective BRCA1 gene mutation detection strategy, and to document genotype-phenotype correlations in mutation carriers. The entire BRCA1 gene was analysed in 75 breast cancer and 30 ovarian cancer patients. Screening for three mutations (5382insC, 4154delA and 300T>G) was carried out...

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Source

Identifiers

PMID: 15951956
DOI: 10.1007/s10689-004-2758-3

Genes

BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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