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Article

Expression of hepcidin is down-regulated in TfR2 mutant mice manifesting a phenotype of hereditary hemochromatosis.

Blood - 1 Jan 2005

Kawabata Hiroshi, Fleming Robert E, Gui Dorina, Moon Seo Y, Saitoh Takayuki, O'Kelly James, Umehara Yutaka, Wano Yuji, Said Jonathan W, Koeffler H Phillip

Abstract excerpt

Transferrin receptor 2 (TfR2) is a membrane glycoprotein that mediates cellular iron uptake from holotransferrin. Homozygous mutations of this gene cause one form of hereditary hemochromatosis in humans. We recently reported that homozygous TfR2(Y245X) mutant mice, which correspond to the TfR2(Y2...

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Source

Identifiers

PMID: 15345587
DOI: 10.1182/blood-2004-04-1416

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-15345587-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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Expression of hepcidin is down-regulated in TfR2 mutant mice manifesting a phenotype of hereditary hemochromatosis.PMID 15345587Read ↗

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