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Article

Key role of conserved histidines in recombinant mouse beta-carotene 15,15'-monooxygenase-1 activity.

The Journal of biological chemistry - 12 Aug 2005

Poliakov Eugenia, Gentleman Susan, Cunningham Francis X, Miller-Ihli Nancy J, Redmond T Michael

Abstract excerpt

Alignment of sequences of vertebrate beta-carotene 15,15'-monooxygenase-1 (BCMO1) and related oxygenases revealed four perfectly conserved histidines and five acidic residues (His172, His237, His308, His514, Asp52, Glu140, Glu314, Glu405, and Glu457 in mouse BCMO1). Because BCMO1 activity is iron-dependent, we propose that these residues participate in iron coordination and therefore are essential for catalytic...

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PMID: 15951442
DOI: 10.1074/jbc.M500409200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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