Article
Primary sclerosing cholangitis in two brothers: report of a family with special emphasis on molecular HLA and MICA genotyping.
European journal of gastroenterology & hepatology - 1 Jul 2005
Van Steenbergen Werner, De Goede Eric, Emonds Marie-Paule, Reinders Judith, Tilanus Marcel, Fevery Johan
Abstract excerpt
Immune mechanisms play a role in the pathogenesis of primary sclerosing cholangitis (PSC), as suggested by its association with certain HLA haplotypes. Genetic predisposition is supported by its occurrence in families, but data are scarce. Our aim is to report on two brothers with PSC, and to investigate HLA and MICA alleles in this family. The clinical, biochemical, radiological, and pathological findings in two...
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