Article
Progressive multifocal leukoencephalopathy after natalizumab therapy for Crohn's disease.
The New England journal of medicine - 28 Jul 2005
Van Assche Gert, Van Ranst Marc, Sciot Raf, Dubois Bénédicte, Vermeire Séverine, Noman Maja, Verbeeck Jannick, Geboes Karel, Robberecht Wim, Rutgeerts Paul
Abstract excerpt
The prior diagnosis of fatal astrocytoma in a 60-year-old man with Crohn's disease treated with natalizumab, a monoclonal antibody against alpha4 integrins, was reclassified as JC virus-related progressive multifocal leukoencephalopathy (PML). Analysis of frozen serum samples showed that JC virus DNA had appeared in the serum three months after the initiation of open-label natalizumab monotherapy and two months...
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