Article
Associations between frequencies of a susceptible TNF-alpha promoter allele and protective alpha-thalassaemias and malaria parasite incidence in Vanuatu.
Tropical medicine & international health : TM & IH - 1 Jun 2005
Ubalee R, Tsukahara T, Kikuchi M, Lum J K, Dzodzomenyo M, Kaneko A, Hirayama K
Abstract excerpt
Tumour necrosis factor-alpha (TNF-alpha) is one of the key cytokines that influence the pathology of microbial infections. The genetic susceptibility to severe forms of falciparum malaria is differentially associated with TNF-alpha promoter gene polymorphisms (TNFP alleles). In a previous study, we identified a TNFP-allele characterized by a C to T transition at position -857 (TNFP-D allele) as a marker for...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.