Article
Characterization of two avian MHC-like genes reveals an ancient origin of the CD1 family.
Proceedings of the National Academy of Sciences of the United States of America - 14 Jun 2005
Miller Marcia M, Wang Carren, Parisini Emilio, Coletta Ricardo D, Goto Ronald M, Lee Stella Y, Barral Duarte C, Townes Maria, Roura-Mir Carme, Ford Heide L, Brenner Michael B, Dascher Christopher C
Abstract excerpt
Many of the genes that comprise the vertebrate adaptive immune system are conserved across wide evolutionary time scales. Most notably, homologs of the mammalian MHC gene family have been found in virtually all jawed vertebrates, including sharks, bony fishes, reptiles, and birds. The CD1 family of antigen-presenting molecules are related to the MHC class I family but have evolved to bind and present lipid...
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