Article
The properties of the single chicken MHC classical class II alpha chain ( B-LA) gene indicate an ancient origin for the DR/E-like isotype of class II molecules.
Immunogenetics - 1 Dec 2003
Salomonsen Jan, Marston Denise, Avila David, Bumstead Nat, Johansson Brit, Juul-Madsen Helle, Olesen Gerda D, Riegert Patricia, Skjødt Karsten, Vainio Olli, Wiles Michael V, Kaufman Jim
Abstract excerpt
In mammals, there are MHC class II molecules with distinctive sequence features, such as the classical isotypes DR, DQ and DP. These particular isotypes have not been reported in non-mammalian vertebrates. We have isolated the class II (B-L) alpha chain from outbred chickens as the basis for the cloning and sequencing of the cDNA. We found only one class II alpha chain transcript, which bears the major features...
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