Article
Evidence for a major gene affecting the transition from normoglycaemia to hyperglycaemia in Psammomys obesus.
Heredity - 1 Aug 2005
Hillel J, Gefel D, Kalman R, Ben-Ari G, David L, Orion O, Feldman M W, Bar-On H, Blum S, Raz I, Schaap T, Shpirer I, Lavi U, Shafrir E, Ziv E
Abstract excerpt
We investigated the mode of inheritance of nutritionally induced diabetes in the desert gerbil Psammomys obesus (sand rat), following transfer from low-energy (LE) to high-energy (HE) diet which induces hyperglycaemia. Psammomys selected for high or low blood glucose level were used as two parental lines. A first backcross generation (BC(1)) was formed by crossing F(1) males with females of the diabetes-prone...
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