Article
[HLA-DRB1 alleles and rheumatoid arthritis in northern Italy: lack of correlation with disease severity and extra-articular manifestations].
Recenti progressi in medicina - 1 Mar 2005
Beri Ruggero, Peterlana Dimitri, Puccetti Antonio, Simeoni Sara, Garzotti Paolo, Biasi Domenico, Caramaschi Paola, Tinazzi Elisa, Lunardi Claudio
Abstract excerpt
We studied HLA-DRB1 alleles in 101 patients with rheumatoid arthritis (RA) and 229 normal subjects by polymerase chain reaction and sequence-specific oligonuclotide hybridization. We observed a statistically significant association between HLA-DR4 and RA (p = 0,0088). This association was not observed for the DR1 status. No particular DR4 suballeles were preferentially expressed in patients. Allele *0102 was more...
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