Article
[Systemic manifestations of rheumatoid arthritis: prognostic value of the HLA DRB1 0405 allele].
La Revue de medecine interne - 1 Jan 1993
Flipo R M, Danze P M, Castelain V, Coquerel P, Duquesnoy B, Rousseaux J, Delcambre B
Abstract excerpt
The aim of the present study was to determine HLA DRB1* genotype by PCR-RFLP analysis in patients with rheumatoid arthritis (N = 122) associated with extra-articular manifestations (N = 24). A significant increased of DRB1* 0405 was found in RA patients with extra-cellular involvement (odd-ratio = 8.33, confidence interval = 1.44 - 56.7). In patients with RA, HLA DRB1*0405 allele might constitute a susceptibility...
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