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Article

Clinical use of genotype to predict chemosensitivity in oligodendroglial tumors.

Neurology - 13 Jun 2006

Walker C, Haylock B, Husband D, Joyce K A, Fildes D, Jenkinson M D, Smith T, Broome J, du Plessis D G, Warnke P C

Abstract excerpt

BACKGROUND: The -1p/-19q genotype has been associated with prolonged survival and chemosensitivity in oligodendroglial neoplasms, but the predictive and prognostic significance of genotype in the routine clinic is not established. METHODS: The authors investigated allelic imbalance in 1p36, 19q13, 17p13, 10p12-15, and 10q22-26 and p53 mutation in a cohort representative of clinical practice at their center (50...

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PMID: 16769937
DOI: 10.1212/01.wnl.0000218270.12495.9a

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