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Article

A novel strategy to identify the location of necessary and sufficient cis-acting regulatory mRNA elements in trypanosomes.

RNA (New York, N.Y.) - 1 Jul 2005

Webb Helena, Burns Roisin, Kimblin Nicola, Ellis Louise, Carrington Mark

Abstract excerpt

Expression of nearly all protein coding genes in trypanosomes is regulated post-transcriptionally, predominantly at the level of mRNA half-life. The identification of cis-acting elements involved in mRNA stability has been hindered by a lack of ability to screen for loss-of-regulation mutants. The method described in this article allows the region containing the necessary and sufficient elements within a mRNA to...

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Identifiers

PMID: 15928343
DOI: 10.1261/rna.2510505
PMCID: PMC1360220

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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