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Article

Resistance to a new catecholic cephem, BO-1341, in Pseudomonas aeruginosa PAO.

The Journal of antimicrobial chemotherapy - 1 Mar 1992

Hazumi N, Matsuda K, Sanada M, Ohtake N, Tanaka N

Abstract excerpt

Two distinct types of mutant resistant to the catecholic cephem BO-1341 were isolated spontaneously from Pseudomonas aeruginosa PAO2146: (i) a mutant (CCB5-type) which produced beta-lactamase constitutively, and which appeared to result from a mutation in the regulatory gene (blaI at 41 min) controlling the structural gene (blaP at 25 min); (ii) a mutant (CCB7-type) with specific resistance to BO-1341. Induction...

Topics

Cefoxitin
Ceftazidime
Cephalosporins
Chlorides
Drug Resistance, Microbial
Enzyme Induction
Ferric Compounds
Microbial Sensitivity Tests
Mutation
Pseudomonas aeruginosa
beta-Lactamases

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Identifiers

PMID: 1592698
DOI: 10.1093/jac/29.3.287

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1592698-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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