Article
Resistance to a new catecholic cephem, BO-1341, in Pseudomonas aeruginosa PAO.
The Journal of antimicrobial chemotherapy - 1 Mar 1992
Hazumi N, Matsuda K, Sanada M, Ohtake N, Tanaka N
Abstract excerpt
Two distinct types of mutant resistant to the catecholic cephem BO-1341 were isolated spontaneously from Pseudomonas aeruginosa PAO2146: (i) a mutant (CCB5-type) which produced beta-lactamase constitutively, and which appeared to result from a mutation in the regulatory gene (blaI at 41 min) controlling the structural gene (blaP at 25 min); (ii) a mutant (CCB7-type) with specific resistance to BO-1341. Induction...
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