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Article

Genetic prognostic and predictive markers in colorectal cancer.

Nature reviews. Cancer - 1 Jul 2009

Walther Axel, Johnstone Elaine, Swanton Charles, Midgley Rachel, Tomlinson Ian, Kerr David

Abstract excerpt

Despite many studies of the likely survival outcome of individual patients with colorectal cancer, our knowledge of this subject remains poor. Until recently, we had virtually no understanding of individual responses to therapy, but the discovery of the KRAS mutation as a marker of probable failure of epidermal growth factor receptor (EGFR)-targeted therapy is a first step in the tailoring of treatment to the...

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PMID: 19536109
DOI: 10.1038/nrc2645

Genes

EGFR
KRAS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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