Low complex ganglioside expression characterizes human neuroblastoma cell lines.

doi:10.1016/j.canlet.2004.11.036

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Article

Low complex ganglioside expression characterizes human neuroblastoma cell lines.

Cancer letters - 8 Jul 2005

Hettmer Simone, Ladisch Stephan, Kaucic Karen

Abstract excerpt

Low (< or = 35%) or absent expression of the complex 'b' pathway gangliosides GD1b, GT1b and GQ1b (CbG) correlates with an aggressive biological phenotype in human neuroblastoma tumors. To develop an in vitro model to probe mechanisms by which CbG may contribute to neuroblastoma behavior, we have comprehensively evaluated ganglioside expression in nine well-established human neuroblastoma cell lines, all derived...

Topics

Cell Survival
Chromatography, Thin Layer
Gangliosides
Gene Expression Profiling
Humans
Neuroblastoma
Phenotype
Prognosis
Tumor Cells, Cultured

Source

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Identifiers

PMID: 15922866
DOI: 10.1016/j.canlet.2004.11.036
PMCID: PMC2866625

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