Article
Spectrum of beta-globin gene mutations among thalassemia patients in the West Bank region of Palestine.
Hemoglobin - 1 Jan 2005
Darwish Hisham M, El-Khatib Fadia F, Ayesh Suhail
Abstract excerpt
beta-Thalassemia (thal) is an autosomal recessive disorder that results in hypochromic hemolytic anemia in affected patients. In the West Bank area of Palestine, the prevalence of beta-thal trait is approximately 3.5% among the population, with an estimated 120,000 carriers. Seventeen beta-globin gene mutations could be identified in 148 patients using polymerase chain reaction (PCR), amplification refractory...
Topics
- Adolescent
- Adult
- Aged
- Alleles
- Child
- Child, Preschool
- DNA Mutational Analysis
- Female
- Genotype
- Globins
- Hemoglobins, Abnormal
- Heterozygote