Article
The beta+-IVS-I-6 (T-->C) mutation accounts for half of the thalassemia chromosomes in the Palestinian populations of the mountain regions.
Hemoglobin - 1 Feb 2002
El-Latif Mahmoud Abd, Filon Dvora, Rund Deborah, Oppenheim Ariella, Kanaan Moien
Abstract excerpt
A study of the spectrum of beta-thalassemia mutations in the southern part of the West Bank of the Palestinian Authority revealed the presence of 10 different beta-globin mutations. The study included 41 patients and 54 carriers of beta-thalassemia and sickle cell anemia. The spectrum of mutations observed was typically Mediterranean. However, their relative frequencies was unique. The predominant allele was...
Topics
- Adolescent
- Adult
- Amino Acid Substitution
- Arabs
- Chromosomes, Human, Pair 11
- Codon
- Codon, Nonsense
- DNA Mutational Analysis
- Female
- Founder Effect
- Frameshift Mutation