Article
The spectrum of β-thalassemia mutations in Gaza Strip, Palestine.
Blood cells, molecules & diseases - 1 Apr 2013
Sirdah Mahmoud M, Sievertsen Jürgen, Al-Yazji Mansour S, Tarazi Issa S, Al-Haddad Ramy M, Horstmann Rolf D, Timmann Christian
Abstract excerpt
BACKGROUND: β-Thalassemia is a disorder caused by mutations at the hemoglobin β-gene (HBB) locus. Its most important manifestation, the major form, is characterized by severe hypochromic and hemolytic anemia and is inherited in an autosomal recessive mode. In Gaza Strip, Palestine 0.02% of the population has been identified as β-thalassemia major. DESIGN AND METHODS: An assessment of mutations was performed in 49...
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