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Article

Mutant human cytomegalovirus lacking the immediate-early TRS1 coding region exhibits a late defect.

Journal of virology - 1 Dec 2002

Blankenship Catherine A, Shenk Thomas

Abstract excerpt

The human cytomegalovirus IRS1 and TRS1 open reading frames encode immediate-early proteins with identical N-terminal domains and divergent C-terminal regions. Both proteins have been shown previously to activate reporter genes in transfection assays in cooperation with other viral gene products. We have constructed two viruses carrying substitution mutations within either the IRS1 or TRS1 open reading frame....

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Source

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Identifiers

PMID: 12414969
DOI: 10.1128/jvi.76.23.12290-12299.2002
PMCID: PMC136912

Genes

IRS1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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