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Article

Electrostatic mechanism of nucleosomal array folding revealed by computer simulation.

Proceedings of the National Academy of Sciences of the United States of America - 7 Jun 2005

Sun Jian, Zhang Qing, Schlick Tamar

Abstract excerpt

Although numerous experiments indicate that the chromatin fiber displays salt-dependent conformations, the associated molecular mechanism remains unclear. Here, we apply an irregular Discrete Surface Charge Optimization (DiSCO) model of the nucleosome with all histone tails incorporated to describe by Monte Carlo simulations salt-dependent rearrangements of a nucleosomal array with 12 nucleosomes. The ensemble of...

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Identifiers

PMID: 15919827
DOI: 10.1073/pnas.0408867102
PMCID: PMC1140479

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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