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Article

Occurrence of hypermutable Pseudomonas aeruginosa in cystic fibrosis patients is associated with the oxidative stress caused by chronic lung inflammation.

Antimicrobial agents and chemotherapy - 1 Jun 2005

Ciofu Oana, Riis Bente, Pressler Tacjana, Poulsen Henrik Enghusen, Høiby Niels

Abstract excerpt

Oxidative stress caused by chronic lung inflammation in patients with cystic fibrosis (CF) and chronic lung infection with Pseudomonas aeruginosa is characterized by the reactive oxygen species (ROS) liberated by polymorphonuclear leukocytes (PMNs). We formulated the hypothesis that oxidation of the bacterial DNA by ROS presents an increased risk for the occurrence of hypermutable P. aeruginosa. The occurrence of...

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Identifiers

PMID: 15917521
DOI: 10.1128/AAC.49.6.2276-2282.2005
PMCID: PMC1140492

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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