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Article

Increased mutability of Pseudomonas aeruginosa in biofilms.

The Journal of antimicrobial chemotherapy - 1 May 2008

Driffield K, Miller K, Bostock J M, O'Neill A J, Chopra I

Abstract excerpt

OBJECTIVES: Isolates of Pseudomonas aeruginosa from cystic fibrosis (CF) patients are frequently hypermutable due to selection of mutants with defects in DNA repair genes such as mutS. Since P. aeruginosa grows as a biofilm within the infected CF lung, it is possible that this mode of growth enhances the mutability of the organism thereby increasing the opportunity to derive permanent hypermutators through...

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Source

Identifiers

PMID: 18256114
DOI: 10.1093/jac/dkn044

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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