Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Sub-lethal concentrations of antibiotics increase mutation frequency in the cystic fibrosis pathogen <i>Pseudomonas aeruginosa</i>

3 Dec 2012

Abstract excerpt

Approximately 80% of adult patients with cystic fibrosis (CF) become chronically infected with Pseudomonas aeruginosa and consequently require antibiotic therapy at intervals throughout their lives. Achieving lethal concentrations of antibiotics in the lung remains a challenge. Recent evidence from Escherichia coli and Staphylococcus aureus suggests that the generation of hydroxyl radicals by sublethal...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antibiotic Resistance in Bacteria
Share to Cystic Fibrosis Research Advances
Share to Vibrio bacteria research studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 23206221
DOI: 10.1111/lam.12032

Provenance

PubMed metadata and Literature Corpus relationships.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Sub-lethal concentrations of antibiotics increase mutation frequency in the cystic fibrosis pathogen <i>Pseudomonas aeruginosa</i>PMID 23206221Read ↗

The Effects of Sub-inhibitory Antibiotic Concentrations on Pseudomonas aeruginosa: Reduced Susceptibility Due to MutationsSemantic proximity Read ↗

Mitomycin C Retains Efficacy after Adaptive Laboratory Evolution of <i>Staphylococcus aureus</i>Semantic proximity Read ↗

Hypermutator <i>Pseudomonas aeruginosa</i> exploits multiple genetic pathways to develop multidrug resistance during long-term infections in the airways of cystic fibrosis patientsSemantic proximity Read ↗

Antibiotic resistance in Pseudomonas aeruginosa strains with increased mutation frequency due to inactivation of the DNA oxidative repair system.Semantic proximity Read ↗

Cationic Peptides Facilitate Iron-induced Mutagenesis in BacteriaSemantic proximity Read ↗

Selection for <i>Staphylococcus aureus</i> small-colony variants due to growth in the presence of <i>Pseudomonas aeruginosa</i>Semantic proximity Read ↗

Hypermutation is a key factor in development of multiple-antimicrobial resistance in Pseudomonas aeruginosa strains causing chronic lung infections.Semantic proximity Read ↗

The problems of antibiotic resistance in cystic fibrosis and solutions.Semantic proximity Read ↗

Emergence of a <i>Pseudomonas aeruginosa</i> Hypermutator Strain During the Course of Ventilator-Associated PneumoniaSemantic proximity Read ↗

Stage‐Specific Adaptation of Hypermutable<i>Pseudomonas aeruginosa</i>Isolates during Chronic Pulmonary Infection in Patients with Cystic FibrosisSemantic proximity Read ↗

<i>Pseudomonas aeruginosa</i> increases the sensitivity of biofilm-grown <i>Staphylococcus aureus</i> to membrane-targeting antiseptics and antibioticsSemantic proximity Read ↗

Hypermutation and the preexistence of antibiotic-resistant Pseudomonas aeruginosa mutants: implications for susceptibility testing and treatment of chronic infections.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.