Article
Human prion diseases with variant prion protein.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences - 29 Mar 1994
Kitamoto T, Tateishi J
Abstract excerpt
Recent molecular genetic studies revealed that the human prion protein (PrP) gene has a large repertoire of polymorphisms and mutations. Each variant PrP seems to correspond to a distinct type of prion diseases. We report herein that it is useful to classify prion diseases into plaque type or non-plaque type, based on the distribution of PrP in the central nervous system. The variant PrP including codon 102,...
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