Article
Variations in COL15A1 and COL18A1 influence age of onset of primary open angle glaucoma.
Clinical genetics - 1 Aug 2013
Wiggs J L, Howell G R, Linkroum K, Abdrabou W, Hodges E, Braine C E, Pasquale L R, Hannon G J, Haines J L, John S W M
Abstract excerpt
Primary open angle glaucoma (POAG) is a genetically and phenotypically complex disease that is a leading cause of blindness worldwide. Previously we completed a genome-wide scan for early-onset POAG that identified a locus on 9q22 (GLC1J). To identify potential causative variants underlying GLC1J, we used targeted DNA capture followed by high throughput sequencing of individuals from four GLC1J pedigrees,...
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