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Article

A mutant cardiac sodium channel with multiple biophysical defects associated with overlapping clinical features of Brugada syndrome and cardiac conduction disease.

Cardiovascular research - 1 Feb 2002

Shirai Nobumasa, Makita Naomasa, Sasaki Koji, Yokoi Hisataka, Sakuma Ichiro, Sakurada Harumizu, Akai Jun, Kimura Akinori, Hiraoka Masayasu, Kitabatake Akira

Abstract excerpt

OBJECTIVE: Loss of Na(+) channel function has been implicated in idiopathic ventricular fibrillation (IVF) and Brugada syndrome. We have studied the biophysical properties of an IVF mutation (S1710L) that exhibited an unusual clinical phenotype: rate-dependent bundle branch block without manifestation of Brugada-type ECG pattern. METHODS: The mutant S1710L channels were expressed in mammalian cells and their...

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PMID: 11827685
DOI: 10.1016/s0008-6363(01)00494-1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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