Article
A mutant cardiac sodium channel with multiple biophysical defects associated with overlapping clinical features of Brugada syndrome and cardiac conduction disease.
Cardiovascular research - 1 Feb 2002
Shirai Nobumasa, Makita Naomasa, Sasaki Koji, Yokoi Hisataka, Sakuma Ichiro, Sakurada Harumizu, Akai Jun, Kimura Akinori, Hiraoka Masayasu, Kitabatake Akira
Abstract excerpt
OBJECTIVE: Loss of Na(+) channel function has been implicated in idiopathic ventricular fibrillation (IVF) and Brugada syndrome. We have studied the biophysical properties of an IVF mutation (S1710L) that exhibited an unusual clinical phenotype: rate-dependent bundle branch block without manifest...
Topics
- Analysis of Variance
- Arrhythmias, Cardiac
- Bundle-Branch Block
- Cell Line
- Electrocardiography
- Heart Conduction System
- Humans
- Ion Channel Gating
- Mutation
- Myocardium
- Patch-Clamp Techniques
- Sodium Channels
- Syndrome