Article
Formation of A2143G mutation of 23S rRNA in progression of clarithromycin resistance in Helicobacter pylori 26695.
Microbial drug resistance (Larchmont, N.Y.) - 1 Jan 2005
Shen Jing, Zhang Jian-Zhong, Ke Yang, Deng Dajun
Abstract excerpt
The aim of this work was to investigate the link between 23S rRNA mutation and clarithromycin (CLR)-resistant Helicobacter pylori (H. pylori). CLR-resistant (CLRr) H. pylori strains were selected from the parent strain, H. pylori 26695, using medium containing CLR. Point mutations of 23S rRNA were analyzed by denaturing high-performance liquid chromatography and sequencing and restriction fragment length...
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