Article
Discovery of novel mutations for clarithromycin resistance in Helicobacter pylori by using next-generation sequencing.
The Journal of antimicrobial chemotherapy - 1 Jul 2014
Binh Tran Thanh, Shiota Seiji, Suzuki Rumiko, Matsuda Miyuki, Trang Tran Thi Huyen, Kwon Dong Hyeon, Iwatani Shun, Yamaoka Yoshio
Abstract excerpt
OBJECTIVES: Resistance to clarithromycin is the most important factor causing failure of Helicobacter pylori eradication. Although clarithromycin resistance is mainly associated with three point mutations in the 23S rRNA genes, it is unclear whether other mutations are associated with this resistance. METHODS: Two types of clarithromycin-resistant strains (low- and high-resistance strains) were obtained from...
Topics
- Anti-Bacterial Agents
- Clarithromycin
- Cluster Analysis
- DNA Mutational Analysis
- DNA, Bacterial
- DNA, Ribosomal
- Drug Resistance, Bacterial
- Genes, Bacterial
- Helicobacter pylori
- High-Throughput Nucleotide Sequencing
- Humans
- Microbial Sensitivity Tests