Article
Application of next-generation sequencing to characterize novel mutations in clarithromycin-susceptible Helicobacter pylori strains with A2143G of 23S rRNA gene.
Annals of clinical microbiology and antimicrobials - 22 Mar 2018
Chen Jiaoe, Ye Liping, Jin Liangmin, Xu Xuehua, Xu Peisong, Wang Xianjun, Li Hongzhang
Abstract excerpt
BACKGROUND: Clarithromycin (CLR) resistance has become a predominant factor for treatment failure of Helicobacter pylori eradication. Although the molecular mechanism of CLR resistance has been clearly understood in H. pylori, it is lack of evidence of other genes involved in drug resistance. Furthermore, the molecular mechanism of phenotype susceptible to CLR while genotype of 23S rRNA is mutant with A2143G is...
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