Article
Mutations in the 23S rRNA gene of clarithromycin-resistant Helicobacter pylori from Japan.
International journal of antimicrobial agents - 1 Sept 2007
Rimbara Emiko, Noguchi Norihisa, Kijima Hidenobu, Yamaguchi Tai, Kawai Takashi, Sasatsu Masanori
Abstract excerpt
The 23S rRNA gene in clinical isolates of Helicobacter pylori isolated between 1995 and 2004 from Japan was investigated and the relationship between mutations in this gene and clarithromycin susceptibility was studied. Among nine mutations that have previously been reported to confer clarithromycin resistance, an adenine-->guanine transition at position 2142 (A2142G) or 2143 (A2143G) was detected in all...
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