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Alpha-1-antichymotrypsin gene polymorphism and susceptibility to multiple system atrophy (MSA).

Brain research. Molecular brain research - 18 Aug 2005

Furiya Yoshiko, Hirano Makito, Kurumatani Norio, Nakamuro Takuya, Matsumura Ryusuke, Futamura Naonobu, Ueno Satoshi

Abstract excerpt

We investigated three genotypes (AA, AT, and TT) produced by signal peptide polymorphism of the alpha-1-antichymotrypsin (ACT) gene in 105 patients with multiple system atrophy (MSA) and age-matched controls. The frequency of ACT-AA genotype was significantly higher in patients with MSA (20.0%) than in controls (10.5%). The onset of MSA was significantly earlier and the disease progressed significantly faster in...

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PMID: 15907346
DOI: 10.1016/j.molbrainres.2005.04.011

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