Article
Association of alpha1-antichymotrypsin polymorphism with cerebral amyloid angiopathy.
Annals of neurology - 1 Jul 1998
Yamada M, Sodeyama N, Itoh Y, Suematsu N, Otomo E, Matsushita M, Mizusawa H
Abstract excerpt
In search of genetic risk factors of sporadic cerebral amyloid angiopathy (CAA), we investigated the association of a polymorphism in the signal peptide sequence of alpha1-antichymotrypsin (ACT) with the severity of CAA in 155 autopsy cases of the elderly, including 48 patients with Alzheimer's d...
Topics
- Aged
- Aged, 80 and over
- Alzheimer Disease
- Autopsy
- Brain
- Brain Chemistry
- Cerebral Amyloid Angiopathy
- Chi-Square Distribution
- DNA
- Gene Frequency
- Genotype
- Humans
- Immunohistochemistry
- Middle Aged
- Polymorphism, Genetic
- Risk Factors
- Serine Proteinase Inhibitors
- Statistics, Nonparametric