Article
Definition of MHC supertypes through clustering of MHC peptide-binding repertoires.
Methods in molecular biology (Clifton, N.J.) - 1 Jan 2007
Reche Pedro A, Reinherz Ellis L
Abstract excerpt
Identification of peptides that can bind to major histocompatibility complex (MHC) molecules is important for anticipation of T-cell epitopes and for the design of epitope-based vaccines. Population coverage of epitope vaccines is, however, compromised by the extreme polymorphism of MHC molecules, which is in fact the basis for their differential peptide binding. Therefore, grouping of MHC molecules into...
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