Article
E-cadherin is required for gastrulation cell movements in zebrafish.
Mechanisms of development - 1 Jun 2005
Shimizu Takashi, Yabe Taijiro, Muraoka Osamu, Yonemura Shigenobu, Aramaki Shinsuke, Hatta Kohei, Bae Young-Ki, Nojima Hideaki, Hibi Masahiko
Abstract excerpt
E-cadherin is a member of the classical cadherin family and is known to be involved in cell-cell adhesion and the adhesion-dependent morphogenesis of various tissues. We isolated a zebrafish mutant (cdh1(rk3)) that has a mutation in the e-cadherin/cdh1 gene. The mutation rk3 is a hypomorphic allele, and the homozygous mutant embryos displayed variable phenotypes in gastrulation and tissue morphogenesis. The most...
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