Article
Characterization of pathways dependent on the uvsE, uvrA1, or uvrA2 gene product for UV resistance in Deinococcus radiodurans.
Journal of bacteriology - 1 Jun 2005
Tanaka Masashi, Narumi Issay, Funayama Tomoo, Kikuchi Masahiro, Watanabe Hiroshi, Matsunaga Tsukasa, Nikaido Osamu, Yamamoto Kazuo
Abstract excerpt
The genome of a radiation-resistant bacterium, Deinococcus radiodurans, contains one uvsE gene and two uvrA genes, uvrA1 and uvrA2. Using a series of mutants lacking these genes, we determined the biological significance of these components to UV resistance. The UV damage endonuclease (UvsE)-dependent excision repair (UVER) pathway and UvrA1-dependent pathway show some redundancy in their function to counteract...
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