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Article

Bcl10 and MALT1, independent targets of chromosomal translocation in malt lymphoma, cooperate in a novel NF-kappa B signaling pathway.

The Journal of biological chemistry - 1 Jun 2001

Lucas P C, Yonezumi M, Inohara N, McAllister-Lucas L M, Abazeed M E, Chen F F, Yamaoka S, Seto M, Nunez G

Abstract excerpt

At least two distinct recurrent chromosomal translocations have been implicated in the pathogenesis of MALT lymphoma. The first, t(1;14), results in the transfer of the entire Bcl10 gene to chromosome 14 wherein Bcl10 expression is inappropriately stimulated by the neighboring Ig enhancer. The second, t(11;18), results in the synthesis of a novel fusion protein, API2-MALT1. Until now, no common mechanism of...

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Source

Identifiers

PMID: 11262391
DOI: 10.1074/jbc.M009984200

Genes

MALT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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