Article
Bcl10 and MALT1, independent targets of chromosomal translocation in malt lymphoma, cooperate in a novel NF-kappa B signaling pathway.
The Journal of biological chemistry - 1 Jun 2001
Lucas P C, Yonezumi M, Inohara N, McAllister-Lucas L M, Abazeed M E, Chen F F, Yamaoka S, Seto M, Nunez G
Abstract excerpt
At least two distinct recurrent chromosomal translocations have been implicated in the pathogenesis of MALT lymphoma. The first, t(1;14), results in the transfer of the entire Bcl10 gene to chromosome 14 wherein Bcl10 expression is inappropriately stimulated by the neighboring Ig enhancer. The se...
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