Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Prostaglandin D2 induces nuclear import of the sex‐determining factor SOX9 via its cAMP‐PKA phosphorylation

5 May 2005

Abstract excerpt

During mammalian gonadal development, nuclear import/export of the transcription factor SOX9 is a critical step of the Sry-initiated testis-determining cascade. In this study, we identify a molecular mechanism contributing to the SOX9 nuclear translocation in NT2/D1 cells, which is mediated by the prostaglandin D2 (PGD2) signalling pathway via stimulation of its adenylcyclase-coupled DP1 receptor. We find that...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
Share to Sexual Differentiation and Disorders
Share to Sperm and Testicular Function

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 15889150
DOI: 10.1038/sj.emboj.7600660

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Prostaglandin D2 induces nuclear import of the sex‐determining factor SOX9 via its cAMP‐PKA phosphorylationPMID 15889150Read ↗

The PGD2 pathway, independently of FGF9, amplifies SOX9 activity in Sertoli cells during male sexual differentiation.Semantic proximity Read ↗

Gonadal transactivation of STARD1, CYP11A1 and HSD3BSemantic proximity Read ↗

SOX9 Regulates Prostaglandin D Synthase Gene Transcription in Vivo to Ensure Testis DevelopmentSemantic proximity Read ↗

SOX9 and SF1 are involved in cyclic AMP-mediated upregulation of anti-Müllerian gene expression in the testicular prepubertal Sertoli cell line SMAT1Semantic proximity Read ↗

Transcription factor GATA-4 is activated by phosphorylation of serine 261 via the cAMP/protein kinase a signaling pathway in gonadal cells.Semantic proximity Read ↗

Phosphorylation of ATF2 and interaction with NFY induces c-Jun in the gonadotropeSemantic proximity Read ↗

PRKX, a phylogenetically and functionally distinct cAMP-dependent protein kinase, activates renal epithelial cell migration and morphogenesisSemantic proximity Read ↗

The molecular action of testis-determining factors SRY and SOX9.Semantic proximity Read ↗

cAMP–Epac2‐mediated activation of Rap1 in developing male germ cells: RA‐RhoGAP as a possible direct down‐stream effectorSemantic proximity Read ↗

The roles of cyclic nucleotide phosphodiesterases (PDEs) in steroidogenesis.Semantic proximity Read ↗

Compound effects of point mutations causing campomelic dysplasia/autosomal sex reversal upon SOX9 structure, nuclear transport, DNA binding, and transcriptional activation.Semantic proximity Read ↗

The transcription factor CREMtau and cAMP regulate promoter activity of the Na,K-ATPase alpha4 isoform.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.